BioNB 440: Lab 4

Operational amplifier applications, part 2.

Introduction.

This assignment will cover some of the ways you can build circuits using operational amplifiers. The emphisis in this lab will be on practical circuits used in neurobiology.


Procedure:

Download the file opamp2.ewb by right-clicking over the link and saving it to your directory. There are several separate circuits in this file. Each has a specific use in biological electronics. The schematics are split into two parts: part 1, part 2.

Play with the circuits in the file to see how they work. Vary the controls or substitute different component values. Note that the electrometer amplifier will oscillate (just like a real one) if the negative capacitance feedback is set too high. For the filters shown, vary the frequency and observe the response. Be sure to connect the Bode-plotter to the filters to plot their frequency response.

All circuits will be built using LM358 operational amplifiers except the electrometer amplifier, which will use a higher input resistance operational amplifier.


Assignment

Note that in this and every lab assignment the verb build means to construct a circuit on the protoype board whith actual parts. The verb simulate means use Electronics Workbench mathematically simulate the circuit.

  1. The differential amplifier shown in opamp2.ewb is the basic circuit used in almost all physiological a.c. preampllifiers used to record extracellular events. Simulate the circuit given. Measure the gain of the differential amplifier for the common mode 60 Hz noise and for differential mode 100 Hz sources. The ratio of the two gains is called the common mode rejection. Now build the differential amplifier and measure the differential gain, common mode gain and common mode rejection of your circuit at about 60 Hz and about 1000 Hz. At what frequency does the gain start to roll off. Put differently, what is the lowpass frequency of your circuit?

  2. The 60 Hz notch filter described in opamp2.ewb depends on having well matched resistor and capacitor values for high attenuation. Simulate the effect of a 5% variation in the 100k resistors by measuring the attenuation at 60 Hz relative to, say, 600 Hz. Build a notch filter and measure its attenuation, then disassemble the circuit and measure the actual values of each component.

  3. The electrometer amplifier shown in opamp2.ewb is a simplified version of a common circuit used in intracellular recording amplifiers. This head stage has a high input resistance relative to the electrode resistance and supplies a gain of 10. The large time constant of the electrode is reduced by a small amount of positive feedback through the 5 pf capacitor. Simulate the frequency response and rise time of the amplifer as you vary the negative capacitance feedback control. Build the circuit and measure its rise time as a function of the negative capacitance feedback control.

Your lab notes should include the results of the simulations and the actual circuits you built.


August 2005 Copyright Cornell university